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Wheelchair
If, after I die, I find that the Christians were (somehow) right, and I am stood before St. Peter at the Pearly Gates, it will be this very comic that prevents me entry. Mitch Clem: Asshole.
But seriously, I should stress that this strip isn't meant to imply that all people in wheelchairs are assholes, but rather that everyone is an asshole, and sometimes people just happen to have wheelchairs.
Texas, by the way, home state of morbidly obese people in wheelchairs. I sometimes wonder if they just don't feel like walking through a whole Wal-Mart.